The physiology of vitamin K nutriture and vitamin K-dependent protein function in atherosclerosis
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چکیده
منابع مشابه
The physiology of vitamin K nutriture and vitamin K-dependent protein function in atherosclerosis.
Recent advances in the discovery of new functions for vitamin K-dependent (VKD) proteins and in defining vitamin K nutriture have led to a substantial revision in our understanding of vitamin K physiology. The only unequivocal function for vitamin K is as a cofactor for the carboxylation of VKD proteins which renders them active. While vitamin K was originally associated only with hepatic VKD p...
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Abstract Background and Objectives Vitamin K-dependent clotting factor deficiency (VKCFD) is usually an acquired problem due to liver disease, malabsorption, and overdose of warfarin. In the present paper the significance and role of vitamin K-dependent coagulation factors in menorrhagia were evaluated. Case We present a rare case of 43 year woman with acquired vitamin K deficiency and se...
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phylloquinone (vitamin K1) versus menaquinones (vitamins K2), and their relative contribution in meeting the needs for vitamin K, not only for the synthesis of the hepatic coagulation factors but also for the less well understood vitamin K-dependent carboxylation reactions in other tissues such as bone. Largely unanswered questions surround the comparative intermediary metabolism and transport ...
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Four proteins active in blood coagulation have long been known to require vitamin K for their proper biosynthesis: factors II, VII, IX, and X. This paper describes the purification of a hitherto unrecognized vitamin K-dependent glycoprotein from bovine plasma. The biosynthesis of this protein is interfered with by the vitamin K antagonist Dicoumarol. The molecular weight of the protein is appro...
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ژورنال
عنوان ژورنال: Journal of Thrombosis and Haemostasis
سال: 2004
ISSN: 1538-7933,1538-7836
DOI: 10.1111/j.1538-7836.2004.00968.x